2-(2-苯乙基)色酮类化合物的生物活性及其生物合成研究进展

肖梦君, 高志晖, 魏建和

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (23) : 1909-1918.

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中国药学杂志
PDF(1994 KB)
中国药学杂志 ›› 2019, Vol. 54 ›› Issue (23) : 1909-1918. DOI: 10.11669/cpj.2019.23.001
中药沉香的研发和应用专刊

2-(2-苯乙基)色酮类化合物的生物活性及其生物合成研究进展

  • 肖梦君1, 高志晖1*, 魏建和1,2*
作者信息 +

Advances in Research on Bioactivity and Biosynthesis of 2-(2-Phenylethyl) Chromones

  • XIAO Meng-jun1, GAO Zhi-hui1*, WEI Jian-he1,2*
Author information +
文章历史 +

摘要

2-(2-苯乙基)色酮类化合物仅分布在少数植物中,具有神经保护、抗菌和抗炎等多种生物活性,是沉香的特征性成分和主要活性成分,具有广阔的药用前景和应用价值。笔者对2-(2-苯乙基)色酮类化合物的神经保护活性、抗肿瘤细胞毒活性、抗菌活性和抗炎活性等生物活性、构效关系及生物合成途径的研究现状进行综述和展望,以期为筛选药用2-(2-苯乙基)色酮类化合物和对其生物合成途径的解析提供参考,并指出了目前生物合成研究中存在的问题。

Abstract

2-(2-Phenylethyl) chromones are only distributed in a few plant species and have many bioactivities such as neuroprotection, antibacterial and anti-inflammatory effects. They are the characteristic and main active components of agarwood. They are expected to have broad medicinal application value. In this paper, the research progress of the biological activities such as neuroprotective activity, anti-tumor cytotoxic activity, antibacterial activity and anti-inflammatory activity, as well as the structure-activity relationship and biosynthetic pathway of 2-(2-phenethyl) chromone compounds were reviewed and prospected. It provides a reference for screening the pharmaceutical 2-(2-phenethyl) chromone compounds and analyzing their biosynthetic pathways. Some problems in the current biosynthesis researches are also pointed out here.

关键词

2-(2-苯乙基)色酮类化合物 / 生物活性 / 生物合成途径

Key words

2-(2-phenylethyl)chromones / bioactivities / biosynthetic pathways

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导出引用
肖梦君, 高志晖, 魏建和. 2-(2-苯乙基)色酮类化合物的生物活性及其生物合成研究进展[J]. 中国药学杂志, 2019, 54(23): 1909-1918 https://doi.org/10.11669/cpj.2019.23.001
XIAO Meng-jun, GAO Zhi-hui, WEI Jian-he. Advances in Research on Bioactivity and Biosynthesis of 2-(2-Phenylethyl) Chromones[J]. Chinese Pharmaceutical Journal, 2019, 54(23): 1909-1918 https://doi.org/10.11669/cpj.2019.23.001
中图分类号： R965   

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基金

中国医学科学院医学与健康科技创新工程资助(重大协同创新项目)(2016-I2M-2-003);国家重点研发计划项目资助(2018YFC1706400);中组部“万人计划”资助(99950534);国家中药材产业技术体系资助(CARS-21)
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